The comparison of complete blood count parameters between acute and chronic peripheral arterial disease
Mehmet Cosgun, Yilmaz Gunes, Asli Kurtar Mansiroglu, Isa Sincer, Gulali Aktas, Tayfur Erdogdu
Recently published data demonstrated that peripheral arterial disease (PAD) is well associated with some hematological parameters. However, data in acute onset PAD is scarce. We aimed to search baseline hematological parameters in angiographically proven lower extremity PAD with chronic and acute thrombotic occlusions. In this retrospective study, angiographically proven 172 PAD patients (121 chronic and 51 acute thrombotic cases) and 80 control subjects (without documented coronary and peripheral arterial disease) were enrolled to this study and divided into three groups as chronic, acute PAD and control groups. Demographic characteristics, laboratory data and angiography findings of the participants were obtained from computerized database and patient files. All groups were statistically similar with regards to baseline clinical and demographic features. WBC and the neutrophils count were found higher whereas the lymphocyte and eosinophil counts were found lower in acute PAD group than chronic PAD and control group. In PAD group (acute and chronic), the median Fontaine stage was significantly positive correlated with N/L ratio and significantly negative correlated with eosinophil count. In multivariable logistic regression analysis, in addition to sex presence of diabetes mellitus and smoking, eosinophil count was found an independent predictor for the development of acute PAD. As well as N/L ratio, eosinophil count is associated with acute development of PAD rather than chronic process and may be used as a diagnostic marker for this purpose in patients undergoing percutaneous intervention.
Keywords: Peripheral arterial disease, neutrophil to lymphocyte ratio, eosinophil, thrombotic occlusion