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International Medical Journal – ISSN : 2147-0634

Protective Effects of Morus Alba (M.alba) Extract on the Alteration of Testicular Tissue and Spermatogenesis in Adult Rats Treated with Monosodium Glutamate

Protective Effects of Morus Alba (M.alba) Extract on the Alteration of Testicular Tissue and Spermatogenesis in Adult Rats Treated with Monosodium Glutamate [English]
Davoud Kianifard
Med-Science. 2015; 4(1): 1959-65
» Abstract & References » PDF Fulltext» doi: 10.5455/medscience.2014.03.8191

Abstract
Various studies have confirmed toxic effects of monosodium glutamate in different organs. The review of literatures about influence of MSG on the male reproductive system shows the variety of tissue damages. Most of these changes mainly manifested by increased oxidative stress and cytotoxicity. The present study was aimed to investigate the possible protective effects of herbal antioxidants (Morus Alba) on the tissue damages related to monosodium glutamate cytotoxicity. Forty-eight adult Wistar rats were divided into two control and experimental groups. Each group divided into short (14 days) and long term (28 days) group. Experimental group was subdivided into four subgroups. The experimental group was injected with MSG (4 mg/kg BW, i.p.). Morus Alba extract (100 mg/kg BW) was administrated to two MSG treated experimental subgroups. At the end of study, the right testis was processed for histological evaluation and the left one was processed for sperm analysis and morphometric studies. Decrease of spermatogenic indices was accompanied with the changes in histomorphology of seminiferous tubules in MSG treated groups. Moreover, the sperm analysis indices were decreased in MSG treated rats. These changes were more obvious in long term treatments. The administration of Morus Alba extract led to improvement in histologic and spermatogenic indices. The most observable improvement in tissue changes was obtained by long term treatment with Morus Alba extract. The present study suggests that the administration of Morus Alba extract can preserve the positive effects in reduction of testicular tissue alterations in Monosodium glutamate tissue toxicity.

Key words: Monosodium glutamate, Morus Alba, rat, spermatogenesis, testicular tissue

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How to Cite this Article
Pubmed StyleKianifard D. Protective Effects of Morus Alba (M.alba) Extract on the Alteration of Testicular Tissue and Spermatogenesis in Adult Rats Treated with Monosodium Glutamate. Med-Science. 2015; 4(1): 1959-65. doi:10.5455/medscience.2014.03.8191


Web StyleKianifard D. Protective Effects of Morus Alba (M.alba) Extract on the Alteration of Testicular Tissue and Spermatogenesis in Adult Rats Treated with Monosodium Glutamate. www.scopemed.org/?mno=166842 [Access: April 19, 2015].doi:10.5455/medscience.2014.03.8191


AMA (American Medical Association) StyleKianifard D. Protective Effects of Morus Alba (M.alba) Extract on the Alteration of Testicular Tissue and Spermatogenesis in Adult Rats Treated with Monosodium Glutamate. Med-Science. 2015; 4(1): 1959-65. doi:10.5455/medscience.2014.03.8191


Vancouver/ICMJE StyleKianifard D. Protective Effects of Morus Alba (M.alba) Extract on the Alteration of Testicular Tissue and Spermatogenesis in Adult Rats Treated with Monosodium Glutamate. Med-Science. (2015), [cited April 19, 2015]; 4(1): 1959-65.doi:10.5455/medscience.2014.03.8191


Harvard StyleKianifard, D. (2015) Protective Effects of Morus Alba (M.alba) Extract on the Alteration of Testicular Tissue and Spermatogenesis in Adult Rats Treated with Monosodium Glutamate. Med-Science, 4 (1), 1959-65. doi:10.5455/medscience.2014.03.8191


Turabian StyleKianifard, Davoud. 2015. Protective Effects of Morus Alba (M.alba) Extract on the Alteration of Testicular Tissue and Spermatogenesis in Adult Rats Treated with Monosodium Glutamate. Medicine Science | International Medical Journal, 4 (1), 1959-65.doi:10.5455/medscience.2014.03.8191


Chicago StyleKianifard, Davoud. “Protective Effects of Morus Alba (M.alba) Extract on the Alteration of Testicular Tissue and Spermatogenesis in Adult Rats Treated with Monosodium Glutamate.” Medicine Science | International Medical Journal 4 (2015), 1959-65.doi:10.5455/medscience.2014.03.8191


MLA (The Modern Language Association) StyleKianifard, Davoud. “Protective Effects of Morus Alba (M.alba) Extract on the Alteration of Testicular Tissue and Spermatogenesis in Adult Rats Treated with Monosodium Glutamate.” Medicine Science | International Medical Journal 4.1 (2015), 1959-65. Print.doi:10.5455/medscience.2014.03.8191


APA (American Psychological Association) StyleKianifard, D. (2015) Protective Effects of Morus Alba (M.alba) Extract on the Alteration of Testicular Tissue and Spermatogenesis in Adult Rats Treated with Monosodium Glutamate. Medicine Science | International Medical Journal, 4 (1), 1959-65.doi:10.5455/medscience.2014.03.8191

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